-SAMe is a very unstable, hygroscopic compound. The most common delivery form is the coated tablet which includes shellacs, waxes, and plastics containing phthalates- known endocrine disruptors. For years, Metabolic Maintenance has avoided these additives by combining SAMe with calcium and magnesium to keep it dry, making small batches, constant refrigeration, and a 6 month shelf-life. Now there is an alternative! One of our trusted ingredient partners, Gnosis S.p. A. of Italy, has found a way to combine SAMe with calcium that makes it shelf-stable at room temperature. We will continue to make small, fresh batches, but we can pass on to our customers the convenience and savings of regular shipping and storage.